Mechanism Found for Destruction of Key Allergy-Inducing Complexes, Researchers Say

[TECH NEWS]

Researchers have learned how a synthetic molecule destroys complexes that induce allergic responses—a discovery that could lead to the development of highly potent, rapidly acting interventions for a host of acute allergic reactions. The study, published online Oct. 28 in Nature, was led by scientists at the Stanford University School of Medicine and the University of Bern, Switzerland. The new inhibitor disarms IgE antibodies, pivotal players in acute allergies, by detaching the antibody from its partner in crime, a molecule called FcR. (Other mechanisms lead to slower-developing allergic reactions.) “It would be an incredible intervention if you could rapidly disconnect IgE antibodies in the midst of an acute allergic response,” said Ted Jardetzky, PhD, professor of structural biology and senior investigator for the study. It turns out the inhibitor used by the team does just that. A myriad of allergens, ranging from ragweed pollen to bee venom to peanuts, can set off IgE antibodies, resulting in allergic reactions within seconds.

October 28, 2012, ScienceDaily, Stanford University Medical Center